The AIM2 Polyclonal Antibody, HRP Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to absent in melanoma 2, and AIM2. This antibody recognizes Human, Mouse, and Rat antigen. The AIM2 Polyclonal Antibody, HRP Conjugated has been validated for the following applications: Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.
Description
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8